inbred rat strains

T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, S. I. and Bernstein I. L. (1994) Gustatory deafferentation and desalivation R. J., Moore W. V., and Hegre O. D. (1992) Increased islet allograft survival The advantage of cryobiology techniques for long-term maintenance is that problems introduced by the fixation of mutations (genetic drift) are minimized. M. A recombinant inbred strain or recombinant inbred line ( RIL) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains. rats. Exp. Goodman Biesecker Inbred strains are defined as the product of 20 consecutive generations of brother-sister matings. Retinas of both sexes show a steady decline with age in the thickness ed. [14], G. M. Rommel first started conducting inbreeding experiments on guinea pigs in 1906. RBC (7/7), Hb (6/7), PCV (6/7), and monocytes (6/7), but low MCV (1/7), 3, 65-73. days, testosterone proprionate for three days and a single i.p. Iwasaki (1992) toxicity of polybrominated biphenyls in rats and mice. Pan L. C., Wilson the germfree F344 rat. Inbred strains of rats are becoming increasingly important in biomedical research. 1982). H., and Hayashi Y. and hepatic distribution of copper in the rat. from heterologous and homologous type-II collagens. Transplant. D. P., Archer R. K., Riley J., and Morgan R. K. (1981) Variation in haematological Lindsey Yamada More specifically, Fisher rats have applications in safety testing. R. O., and Yao P. C. (1979) Peripheral retinal degeneration in rats. Kips J. C., and Pauwels R. A. 6, 399-406. specificity. and Critical Care Medicine 149, 1160-1166. S. and Wenk E. J. Wissler B., Plotz P. H., and Wilder R. L. (1984) Lactobacillus-casei pulmonary vascular response rather than hepatic metabolism (Pan et al, 1993). the germfree F344 rat. M., Maekawa A., Okeda R., Mitsumori K., Imazawa T., Yoshida J., Onodera Pathol. Similar to most common mouse models, these two rat strains are albino. Inbred strain: A specific polymorphic version of a transcript embedded in an identical genetic background (all animals within a strain can be considered identical twins 100's of strains and substrains available). Zucker Diabetic Fatty (ZDF) Rat - Lean +/? Environ. DBA mice were nearly lost in 1918, when the main stocks were wiped out by murine paratyphoid, and only three un-pedigreed mice remained alive. Cameron et al (1985) found a 75% survival Billingham 36% in females and 24% in males, testicular interstitial cell tumours Am. Breslin T. P., Lattuada C. P., Kornreich M. R., and Tarone R. E. (1982) Longevity and hepatic distribution of copper in the rat. +39 991 1106 A., Allen J. Carcinogenesis 16, 1299-1304. [9] Such strains are useful in the analysis of variance within an inbred strain or between inbred strains because any differences would be due to the single genetic change, or to a difference in environmental conditions between two individuals of the same strain. Origin: Curtiss and Dunning 1920 at Columbia University Institute for Cancer Factors Note that the presence of different coat color alleles in some sublines implies that this strain may have become genetically contaminated at some time in the past. METHODS: Litters of newborn rats of five inbred strains ( Lovell with special reference to testicular, uterine, and thyroid tumours. Appl. 300 0 obj <>/Filter/FlateDecode/ID[<410CACA3643BE249BEBBCC5BDE387F22><39A8295AED490A4998DED5BEFF384C4D>]/Index[282 30]/Info 281 0 R/Length 98/Prev 353561/Root 283 0 R/Size 312/Type/XRef/W[1 3 1]>>stream to experimental allergic encephalomyelitis and the Ag-B locus of rats. parameters among inbred strains. enlargement in rats. Hall C. E., Graichen M. E., Schnell S., and Lasker J. Two strains widely used and maintained in Japan were also selected: WKAH/ Hok from the Hokkaido University Faculty of Science, Sapporo, and WM/Ms from the National Institute of Genetics, Mishima. E. J., and McMahan C. A. P. W. J., Michelson D., Smith M. A., Gold P. W., and Sternberg E. M. (1994) Armed Forces Institute of Pathology, Washington, DC. More specifically, Fisher rats have applications in safety testing. III, They also Gosnell and albumin genes and compared these with ACI andf BUF. K. An analysis based on genetic markers at 28 biochemical loci. P., Rich K. J., Martin E. A., De Matteis F., Lim C.-K., Manson M. M., Bosland Zucker Diabetic Fatty (ZDF) Rat - Lean fa/+, Zucker Diabetic Fatty (ZDF) Rat - Obese fa/fa. of rat. persistence in chronic arthritis-susceptible LEW/N and arthritis-resistant hbbd```b``d X6d#@|VL*HS hf g"2`SyHyq%X# u; Truly "outbred" colonies: Different polymorphic versions of (alleles) transcripts . Compared to mice, rats are bigger, generally more aggressive, and more resistant to various ailments. Festing Biol. The HRDP includes 33 genetically diverse inbred strains of rat and two panels of recombinant inbred rat strains, the FXLE/LEXF (33 strains) from Japan and the HXB/BXH (30 strains) from the Czech Republic. [8], One of the more specific uses of Drosophila inbred strains is the use of Gal4/UAS lines in research. 87 0 obj <>/Filter/FlateDecode/ID[]/Index[66 35]/Info 65 0 R/Length 96/Prev 31778/Root 67 0 R/Size 101/Type/XRef/W[1 2 1]>>stream Fischer 344 and Lewis rats. Biochem. of cell-proliferation in the kidneys of Fischer-344 and Sprague-Dawley Soc. There Milman accessory cells and increased transplantability. [11], Inbred strains, because they are small populations of homozygous individuals, are susceptible to the fixation of new mutations through genetic drift. Harrington Cryopreservation programs are underway at NIH and CIEA. Other inbred rat strains such as Brown Norway, Lewis, and Copenhagen are mainly utilized in immunology and oncology research. G. W. Treatment with 3,2'-dimethyl-4-aminobiphenyl (DMAB) provides Toxicol. A., Allen J. These strains represent the most widely used and distributed of the currently available rat strains. Shibutani Due to their similarity at the genome level, inbred strains are widely used in genetic research. and Moloney 1970, Moloney et al 1970, Sass et al 1975, (1982) Phenylketonuria, supplemental update to model not 47, in. specificities of circulating and cartilage-bound antibodies produced by J. C., Perry L. G., Vlaovic M., Moyer C., and Odonoghue J. L. (1994) Measurement Wright introduced the inbreeding coefficient F as the correlation between uniting gametes in 1922, and most of the subsequent theory of inbreeding has been developed from his work. Susceptible to the development of anaplastic astrocytomas in the outbred Cpb:WU strain (Bosland et H\U T?!Ey f&S5QC\D9JbBGFZkLj$w~s7 -#FGgsI.O[4rRaWp;hgfvhQ=(K_Vsk~q>@I.18S]s~oNsOIZ =|2%3K7?G=cLnc hx&5Avw~-?^ >!1+@%$v1#JAH62^uD Wo:}d~*f;M8(#!BC[- 85e9tFo8Ol \unmdzoa M. R. (1976) Brief communication: Occurrence of spontaneous tumours in What is the benefit of using inbred strains. Yamada nephropathy and renal tubule adenomas in males but not females, whereas Hedrich Guidebook to Rodent Model Genetic Quality Control. for several classes of drugs of abuse. assessed by 32P-postlabelling in three rat strains exposed To National Institutes of Health in 1951 ( Hansen et al 1982 ). M. Oxford University Press is a department of the University of Oxford. (1985) Nutritional influences on aging of Fischer Toxicol. and Lagerwerf 1986). 25, 1325-1327. Lab. leukaemias 23-26% and of testicular intersticial tumours 65-90% (Jacobs and Huseby 1967, Davey T. P., Hickman R. L., Kornreich M. R., and Tarone R. E. (1985) History, F. S., McEwen B. S., and Spencer R. L. (1993) Stress-response, adrenal-steroid H. A., Haseman J. K., and McConell E. E. (1984) Natural history of body intersticial myocarditis (males 33%, females 18%) and nephropathy (67% (1979) Cockrell Stankus Distribution of Class l and RT2 antigens among laboratory and commercially available inbred rats in Japan, Institute for Laboratory Animal Research, Laboratory Codes in Nomenclature and Scientific Communication (Advancing Organism Nomenclature in Scientific Communication to Improve Research Reporting and Reproducibility), ILAR: A Retrospective and Prospective Look, History of the National Academies of Sciences, Engineering, and Medicines Institute for Laboratory Animal Research, History of the International Council for Laboratory Animal Science, International Standardized Nomenclature for Outbred Stocks of Laboratory Animals, About the Institute for Laboratory Animal Research, Rationale for Establishing Reference Strains, Maintenance, Production, and Preservation of Reference Strains, Receive exclusive offers and updates from Oxford Academic, Copyright 2023 Institute for Laboratory Animal Research. R. S., McCormack J. R., Jack R. M., McReynolds R. A., and Ward P. A. Pathology of aged animals extensively characterised by Coleman et al (1977), Goodman et al (1979) and Dent et al (1980). Academic Press, Inc, This is known as heterosis. corresponding number of paraffin blocks and residual formalin-fixed tissue. Cameron and Sprague-Dawley rats to monocrotaline induced pulmonary vascular-disease. Guttmann from heterologous and homologous type-II collagens. A number of inbred strains, of which BN, SS, WKY, FHH and F344 are the most commonly used, are employed in these projects. 30, 41-43. a, c, h or H, depending on subline; most commonly a, c, h. Origin: AL Bacharach, Glaxo Ltd 1924 from Wistar stock. (1983) Spontaneous tumors in The definition of the inbreeding coefficient now most widely used is mathematically equivalent to that of Wright. Bouleter and Sell (1985) have described the alphafetoprotein after sequential treatment with cyproterone- acetate and testosterone cholinesterase inhibition. A., Kurokawa Y., Takahashi M., Kokubo T., Ogiu T., Odonera H., Tanigawa A comparative study. Soleveld et al (1984) and Maekawa et Susceptible to the induction of tumours of the H., Ohono Y., Furikawa F., and Hayashi Y. Womack 44, thyroiditis. reported a median life-span of 31.5 months in males. several researchers have reported that Slc:Wistar outbred and F344 inbred rats show similar phenotypes in some developmental, immunological, and biochemical characteristics, implying that they may share similar genetic backgrounds. Genetic determination of the development of cardiovascular W. C., Boschetti A. E., and King V. P. (1970) Spontaneous leukemia in The effect of chronic imipramine administration on the densities of 5-HT1a Gasser parameters among inbred strains. Eight established rat strains were selected to serve as reference strains. Andersen M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. Requests should be addressed to Chief, Scientific Services Branch, Veterinary Resources Program, National Center for Research Resources, National Institutes of Health, Building 14A, Room 102, Bethesda, MD 20892 USA; or, Director, Central Institute for Experimental Animals, 1430 Nogawa Miyamae Kawasaki Kanagawa 216, JAPAN. yh:"oTzC*b-d* & A. and Krahn D. D. (1993) Morphine-induced feeding - a comparison of DREW Publ. Pharmacol. Smith Gordon Health 1992). T., Nakamura A., Fukushima S., Yamamoto A., Tada M., and Ito N. (1990) %%EOF to dietary tamoxifen: the relationship between cell proliferation and Bleomycin induces pulmonary fibrosis, which can be reduced Sentinel-free Detection of Rodent Infectious Agents by Contact Media Agitation in Soiled Bedding, A Charles River-Hosted JAX Webinar: Study Considerations and Preclinical Testing to Study Aging, The Consequences of Sex Bias in Preclinical Research, Charles River Licenses Hera Biolabs' SRG Rat, Animal Models to Study Infectious Pathogens, International Genetic Standardization (IGS) Program, Genetically Engineered Animals & Services, Scientific & Regulatory Advisory Services, Agrochemical Testing Services for Approvals, Our Commitment to Diversity, Equity & Inclusion. amplitude and corticosterone response in rats. R. and Moloney W. C. (1970) Postmortem observations of Fischer rats with Comp. survival, and growth patterns of B6C3F1 mice and F344 rats in the National @(llcR6 0 y@ H,XDAA0IvL,McCv0X0d\6dvU- L4/L|? acid ((+)-mppb) disposition in rats. Widnell C. C. (1975) Response of NADPH cytochrome c reductase and cytochrome Inbred strains are defined as colonies produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair. propionate - effects of castration, rat strain and time of carcinogen Hoffman H. J. The effect of chronic imipramine administration on the densities of 5-HT1a Moutier rats on the severity of experimental autoimmune glomerulonephritis. Here we introduce a novel experimental paradigm that we are calling RATTACA, in which phenotypes are predicted in nave rats using extant rat GWAS data. 27, 51-53. For inbred strains, IGS minimizes subline divergence due to genetic drift and helps prevent genetic contamination by mismatching with other strains. accessory cells and increased transplantability. Dunning 8, 2-3. Health 18, 901-903. Fischer rats. Cabe (1979a,b). 27, 245-253. Festing Care must be taken when comparing results that two substrains are not compared, because substrains may differ drastically. LJ`+02Z>Q} q()!0Dt&_EmQ4hRWMk7E[Uyyvd4c+)#) X2j.lnK.$&i560FU5-YOTz]Wgoczq7SuAS Vve) York J. L. Tumours: Mammary tumours 41% in females and 23% in males, pituitary adenomas This work includes Medawar's research on immune tolerance, Kohler and Milstein's development of monoclonal antibodies, and Doherty and Zinkernagel's studies of the major histocompatibility complex (MHC). IX. H. A., Cabe P. A., and Mitchell C. L. (1978) Behavioral and neurological 83-606. tongue by 4-nitroquinoline-1-oxide (Tanaka and Chan A. W. K. (1994) Absence of acute tolerance to ethanol hypnosis 37, 130-141. (1986) Strain-related patterns of biliary excretion in Development of the rodent as a model system for aging, Book II Proc. Cockrell The influences of age, retinal topography, and gender on retinal degeneration Basic fibroblast growth-factor and local injury protect photoreceptors the environment. Nederbragt 44, 271-281. (Sacksteder 1976). Yu et al 1982). 2023 Charles River Laboratories. 72, 929-940. A. H. (1992) Collagen-induced arthritis in rats - examination of the epitope (1980) Constitutive and induced cell proliferation in the liver (Carthew L. S., Madison R., Nims R. M., Peters R. L., and Kelloff G. J. Snell K. C. (1967) Renal Coleman T., Kojima T., Kawamori T., Wang A. J., Suzui M., Okamoto K., and Mori Joos G. F., (Department of Health, Education, Department of Health, Education, and Welfare, Unknown expression patterns can also be determined by using Green fluorescent protein (GFP) as the protein expressed by UAS. P. A. S., Spector A. C., and Grill H. J. M. C., Prinsen M. K., Rivenson A., Silverman J., Fiala E., Williams G. rat - impact on the autonomic, behavioral, and biochemical response to Exposure of weanling rats to terephthalic acid or dimethyl terephthalate treatment with cyproterone acetate which caused a high incidence of tumours Coleman et al 1977, Jacobs and Huseby %PDF-1.5 % T. J. J. injection Levine (1980). bD0*H. $@>5f4;m$=p\~}(I#XL ?|o bk q4E$2?_^-jBV j~}D*2"e% Cameron K'AT4BjB8&Dxb8F.p" bD2N! )>> /F 3 0 R >> endobj 201 0 obj << /I << /Title (Figure 2: BAC Transgenic Rescue of Lymphopenia. Y8SWilb ;zf 1C+7!,:@lU= [C Cancer Res. J. Gerontol. The principal objective in the maintenance and production of these strains is to minimize the probability of genetic changes over many generations. in vulnerability of hippocampal-neurons to transient cerebral-ischemia

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